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The overarching goal of this notice of funding opportunity (NOFO) and its companion opportunities is to establish the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Program to support development of innovative, reliable, cost-effective, and sustainable multimodal AI-based clinical decision support (CDS) tools. PRIMED-AI CDS tools are based on the integration of clinical imaging with other types of multimodal health data to enhance care for patients with a wide range of health conditions. The PRIMED-AI Program seeks to catalyze the adoption of AI-based CDS tools into clinical workflows to enable novel personalized medicine strategies that address significant health challenges.
The purpose of this NOFO is to solicit applications for the creation of a Validation Center to serve as a dedicated hub for the comprehensive evaluation and characterization of AI-enabled, image-based, multimodal CDS tools developed by the PRIMED-AI Consortium, to ensure these tools are reliable, reproducible, and generalizable. The Validation Center will focus on verification, validation, interoperability, and uncertainty quantification to comprehensively characterize performance of the CDS tools developed by the program. The core functions of the Validation Center will involve the systematic validation of PRIMED-AI Consortium deliverables, including those emerging from award recipients under the Playbook, Data-to-Model Academic-Industrial Partnerships, and Model-to-Clinic NOFOs.
The Validation Center will focus on verification, validation, interoperability, and uncertainty quantification to comprehensively characterize performance of the CDS tools developed by the program. The core functions of the Validation Center will involve the systematic validation of PRIMED-AI Consortium deliverables, including those emerging from award recipients under the Playbook, Data-to-Model Academic-Industrial Partnerships, and Model-to-Clinic NOFOs.
"06""Public and State controlled institutions of higher education""11""Native American tribal organizations (other than Federally recognized tribal governments)""20""Private institutions of higher education""12""Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education""01""County governments""08""Public housing authorities/Indian housing authorities""22""For profit organizations other than small businesses""23""Small businesses""07""Native American tribal governments (Federally recognized)""05""Independent school districts""CA""Cooperative Agreement""HL""Health""11""Native American tribal organizations (other than Federally recognized tribal governments)""20""Private institutions of higher education""04""Special district governments""12""Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education""02""City or township governments""25""Others (see text field entitled \"Additional Information on Eligibility\" for clarification)""23""Small businesses""07""Native American tribal governments (Federally recognized)""05""Independent school districts""06""Public and State controlled institutions of higher education""00""State governments""01""County governments""08""Public housing authorities/Indian housing authorities""22""For profit organizations other than small businesses""13""Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education""CA""Cooperative Agreement""HL""Health""NIH""HHS-NIH11""HHS-NIH11""National Institutes of Health""HHS""HHS""HHS""HHS""Department of Health and Human Services""HHS"{"id":428812,"revision":4,"cfdaNumber":"93.310","programTitle":"Trans-NIH Research Support","opportunityId":359269}10{"revision":0,"opportunityId":359269}"Y""Sep 12, 2025 03:15:39 PM EDT""U""HHS-NIH11"2026false"Jun 06, 2025 11:46:32 AM EDT""Jun 06, 2025 12:00:00 AM EDT""Sep 01, 2026 12:00:00 AM EDT""<p><span style=\"color: rgb(51, 51, 51);\">The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the </span><strong style=\"color: rgb(51, 51, 51);\">Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks </strong><span style=\"color: rgb(51, 51, 51);\">to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’s </span><strong style=\"color: rgb(51, 51, 51);\">Validation Center initiative will serve </strong><span style=\"color: rgb(51, 51, 51);\">as an independent hub for third party verification, validation, and uncertainty quantification of AI-enabled, image-based, multimodal Clinical Decision Support (CDS) tools through the systematic retesting and harmonization of PRIMED-AI deliverables to comprehensively characterize performance of the CDS tools. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U54 activity code. Investigators with expertise and insights into the validation of CDS tools and the confidence bounds and potential failure modes of AI predictions are encouraged to begin to consider applying for this new NOFO. </span></p>"{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}359269[{"id":"20","description":"Private institutions of higher education"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"01","description":"County governments"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"05","description":"Independent school districts"},{"id":"23","description":"Small businesses"}]"2025-06-06-00-00-00""Jun 06, 2025 11:46:32 AM EDT""2026-09-01-00-00-00""Jun 06, 2025 11:46:32 AM EDT""3900000""Sahana N. Kukke, PhD \r\nOffice of the Director/NIH Common Fund, DPCPSI, OD""ODPRIMED-AI@od.nih.gov""301-402-3756""2025-06-06-11-46-32"[{"id":"CA","description":"Cooperative Agreement"}]"Sep 01, 2026 12:00:00 AM EDT""ODPRIMED-AI@od.nih.gov""2026-09-01-00-00-00""Jul 01, 2025 12:00:00 AM EDT""2025-07-01-00-00-00""3,900,000"[{"id":"HL","description":"Health"}]"Nov 01, 2025 12:00:00 AM EDT""2025-11-01-00-00-00"0359269"D""Discretionary"{"id":428812,"revision":4,"cfdaNumber":"93.310","programTitle":"Trans-NIH Research Support","opportunityId":359269}21{"revision":1,"opportunityId":359269}"Y""Jan 21, 2026 11:41:53 AM EST""U""HHS-NIH11"2027false"Jun 06, 2025 11:46:32 AM EDT""Updated all estimated due dates.""Jun 06, 2025 12:00:00 AM EDT""Dec 01, 2026 12:00:00 AM EST""<p><span style=\"color: rgb(51, 51, 51);\">The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the </span><strong style=\"color: rgb(51, 51, 51);\">Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks </strong><span style=\"color: rgb(51, 51, 51);\">to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’s </span><strong style=\"color: rgb(51, 51, 51);\">Validation Center initiative will serve </strong><span style=\"color: rgb(51, 51, 51);\">as an independent hub for third party verification, validation, and uncertainty quantification of AI-enabled, image-based, multimodal Clinical Decision Support (CDS) tools through the systematic retesting and harmonization of PRIMED-AI deliverables to comprehensively characterize performance of the CDS tools. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U54 activity code. Investigators with expertise and insights into the validation of CDS tools and the confidence bounds and potential failure modes of AI predictions are encouraged to begin to consider applying for this new NOFO. </span></p>"{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}359269[{"id":"20","description":"Private institutions of higher education"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"01","description":"County governments"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"05","description":"Independent school districts"},{"id":"23","description":"Small businesses"}]"2025-06-06-00-00-00""Sep 12, 2025 03:15:39 PM EDT""2026-12-01-00-00-00""Sep 12, 2025 03:15:39 PM EDT""3900000""Sahana N. Kukke, PhD \r\nOffice of the Director/NIH Common Fund, DPCPSI, OD""ODPRIMED-AI@od.nih.gov""301-402-3756""2025-09-12-15-15-39"[{"id":"CA","description":"Cooperative Agreement"}]"Dec 01, 2026 12:00:00 AM EST""ODPRIMED-AI@od.nih.gov""2026-12-01-00-00-00""Dec 18, 2025 12:00:00 AM EST""2025-12-18-00-00-00""3,900,000"[{"id":"HL","description":"Health"}]"Feb 18, 2026 12:00:00 AM EST""2026-02-18-00-00-00"1359269"D""Discretionary"{"id":428812,"revision":4,"cfdaNumber":"93.310","programTitle":"Trans-NIH Research Support","opportunityId":359269}32{"revision":2,"opportunityId":359269}"N""Jan 21, 2026 11:43:00 AM EST""U""HHS-NIH11"2027false"Jun 06, 2025 11:46:32 AM EDT""FON updated to reflect the anticipated NOFO.""Jun 06, 2025 12:00:00 AM EDT""Dec 01, 2026 12:00:00 AM EST""<p><span style=\"color: rgb(51, 51, 51);\">The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the </span><strong style=\"color: rgb(51, 51, 51);\">Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks </strong><span style=\"color: rgb(51, 51, 51);\">to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’s </span><strong style=\"color: rgb(51, 51, 51);\">Validation Center initiative will serve </strong><span style=\"color: rgb(51, 51, 51);\">as an independent hub for third party verification, validation, and uncertainty quantification of AI-enabled, image-based, multimodal Clinical Decision Support (CDS) tools through the systematic retesting and harmonization of PRIMED-AI deliverables to comprehensively characterize performance of the CDS tools. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U54 activity code. Investigators with expertise and insights into the validation of CDS tools and the confidence bounds and potential failure modes of AI predictions are encouraged to begin to consider applying for this new NOFO. </span></p>"{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}359269[{"id":"20","description":"Private institutions of higher education"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"01","description":"County governments"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"05","description":"Independent school districts"},{"id":"23","description":"Small businesses"}]"2025-06-06-00-00-00""Jan 21, 2026 11:41:53 AM EST""2026-12-01-00-00-00""Jan 21, 2026 11:41:53 AM EST""3900000""Sahana N. Kukke, PhD \r\nOffice of the Director/NIH Common Fund, DPCPSI, OD""ODPRIMED-AI@od.nih.gov""301-402-3756""2026-01-21-11-41-53"[{"id":"CA","description":"Cooperative Agreement"}]"Dec 01, 2026 12:00:00 AM EST""ODPRIMED-AI@od.nih.gov""2026-12-01-00-00-00""Dec 18, 2025 12:00:00 AM EST""2025-12-18-00-00-00""3,900,000"[{"id":"HL","description":"Health"}]"Feb 18, 2026 12:00:00 AM EST""2026-02-18-00-00-00"2359269"D""Discretionary"{"id":428812,"revision":4,"cfdaNumber":"93.310","programTitle":"Trans-NIH Research Support","opportunityId":359269}43{"revision":3,"opportunityId":359269}"Y""Jun 29, 2026 01:04:17 PM EDT""U""HHS-NIH11"2027false"Jun 06, 2025 11:46:32 AM EDT""Updated all estimated date fields.""Jun 06, 2025 12:00:00 AM EDT""Mar 01, 2027 12:00:00 AM EST""<p><span style=\"color: rgb(51, 51, 51);\">The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the </span><strong style=\"color: rgb(51, 51, 51);\">Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks </strong><span style=\"color: rgb(51, 51, 51);\">to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’s </span><strong style=\"color: rgb(51, 51, 51);\">Validation Center initiative will serve </strong><span style=\"color: rgb(51, 51, 51);\">as an independent hub for third party verification, validation, and uncertainty quantification of AI-enabled, image-based, multimodal Clinical Decision Support (CDS) tools through the systematic retesting and harmonization of PRIMED-AI deliverables to comprehensively characterize performance of the CDS tools. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U54 activity code. Investigators with expertise and insights into the validation of CDS tools and the confidence bounds and potential failure modes of AI predictions are encouraged to begin to consider applying for this new NOFO. </span></p>"{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}359269[{"id":"20","description":"Private institutions of higher education"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"01","description":"County governments"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"05","description":"Independent school districts"},{"id":"23","description":"Small businesses"}]"2025-06-06-00-00-00""Jan 21, 2026 11:43:00 AM EST""2027-03-01-00-00-00""Jan 21, 2026 11:43:00 AM EST""3900000""Sahana N. Kukke, PhD \r\nOffice of the Director/NIH Common Fund, DPCPSI, OD""ODPRIMED-AI@od.nih.gov""301-402-3756""2026-01-21-11-43-00"[{"id":"CA","description":"Cooperative Agreement"}]"Mar 01, 2027 12:00:00 AM EST""ODPRIMED-AI@od.nih.gov""2027-03-01-00-00-00""Apr 01, 2026 12:00:00 AM EDT""2026-04-01-00-00-00""3,900,000"[{"id":"HL","description":"Health"}]"Jun 01, 2026 12:00:00 AM EDT""2026-06-01-00-00-00"3359269"D""Discretionary"{"id":428812,"revision":4,"cfdaNumber":"93.310","programTitle":"Trans-NIH Research Support","opportunityId":359269}55{"revision":5,"opportunityId":359269}"N""Jun 30, 2026 11:02:10 AM EDT""U""HHS-NIH11"2027false"Jun 06, 2025 11:46:32 AM EDT""Updated Opportunity Number and Title to match NOFO.""Jun 06, 2025 12:00:00 AM EDT""Mar 01, 2027 12:00:00 AM EST""<p><span style=\"color: rgb(51, 51, 51);\">The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the </span><strong style=\"color: rgb(51, 51, 51);\">Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks </strong><span style=\"color: rgb(51, 51, 51);\">to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’s </span><strong style=\"color: rgb(51, 51, 51);\">Validation Center initiative will serve </strong><span style=\"color: rgb(51, 51, 51);\">as an independent hub for third party verification, validation, and uncertainty quantification of AI-enabled, image-based, multimodal Clinical Decision Support (CDS) tools through the systematic retesting and harmonization of PRIMED-AI deliverables to comprehensively characterize performance of the CDS tools. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U54 activity code. Investigators with expertise and insights into the validation of CDS tools and the confidence bounds and potential failure modes of AI predictions are encouraged to begin to consider applying for this new NOFO. </span></p>"{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}359269[{"id":"20","description":"Private institutions of higher education"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"01","description":"County governments"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"05","description":"Independent school districts"},{"id":"23","description":"Small businesses"}]"2025-06-06-00-00-00""Jun 29, 2026 01:04:17 PM EDT""2027-03-01-00-00-00""Jun 29, 2026 01:04:17 PM EDT""3900000""Sahana N. Kukke, PhD \r\nOffice of the Director/NIH Common Fund, DPCPSI, OD""ODPRIMED-AI@od.nih.gov""301-402-3756""2026-06-29-13-04-17"[{"id":"CA","description":"Cooperative Agreement"}]"Mar 01, 2027 12:00:00 AM EST""ODPRIMED-AI@od.nih.gov""2027-03-01-00-00-00""Apr 01, 2026 12:00:00 AM EDT""2026-04-01-00-00-00""3,900,000"[{"id":"HL","description":"Health"}]"Jun 01, 2026 12:00:00 AM EDT""2026-06-01-00-00-00"5359269"D""Discretionary"{"id":353493,"fileName":"RFA-RM-27-014-Full-Announcement.html","mimeType":"text/html;charset=UTF-8","createdDate":"Jun 30, 2026 11:02:26 AM EDT","fileLobSize":177973,"opportunityId":359269,"fileDescription":"RFA-RM-27-014-Full-Announcement.html","synopsisAttFolderId":80538}Source: Grants.gov (opportunity 359269), retrieved via the Grants.gov Search API. View the official posting , always confirm requirements and deadlines with the issuing agency.