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The overarching goal of this notice of funding opportunity (NOFO) and its companion opportunities is to establish the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Program to support development of innovative, reliable, cost-effective, and sustainable multimodal AI-based clinical decision support (CDS) tools. PRIMED-AI CDS tools are based on the integration of clinical imaging with other types of multimodal health data to enhance care for patients with a wide range of health conditions. The PRIMED-AI Program seeks to catalyze the adoption of AI-based CDS tools into clinical workflows to enable novel personalized medicine strategies that address significant health challenges.
The purpose of this Notice of Funding Opportunity (NOFO) is to catalyze the development and testing of Artificial Intelligence (AI)-enabled, image-centered, multimodal Clinical Decision Support (CDS) tools, developed in pursuance as Software as a Medical Device (SaMD). These projects are expected to have high potential for demonstrable, positive impact on patient outcomes and/or healthcare processes.
"00""State governments""01""County governments""08""Public housing authorities/Indian housing authorities""12""Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education""06""Public and State controlled institutions of higher education""23""Small businesses""20""Private institutions of higher education""07""Native American tribal governments (Federally recognized)""05""Independent school districts""22""For profit organizations other than small businesses""11""Native American tribal organizations (other than Federally recognized tribal governments)""CA""Cooperative Agreement""HL""Health""00""State governments""08""Public housing authorities/Indian housing authorities""12""Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education""06""Public and State controlled institutions of higher education""25""Others (see text field entitled \"Additional Information on Eligibility\" for clarification)""07""Native American tribal governments (Federally recognized)""05""Independent school districts""01""County governments""02""City or township governments""23""Small businesses""13""Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education""20""Private institutions of higher education""22""For profit organizations other than small businesses""04""Special district governments""11""Native American tribal organizations (other than Federally recognized tribal governments)""CA""Cooperative Agreement""HL""Health""NIH""HHS-NIH11""HHS-NIH11""National Institutes of Health""HHS""HHS""HHS""HHS""Department of Health and Human Services""HHS"{"id":428813,"revision":4,"cfdaNumber":"93.310","programTitle":"Trans-NIH Research Support","opportunityId":359270}10{"revision":0,"opportunityId":359270}"Y""Sep 12, 2025 02:59:34 PM EDT""U""HHS-NIH11"2026false"Jun 06, 2025 11:54:18 AM EDT""Jun 06, 2025 12:00:00 AM EDT""Sep 01, 2026 12:00:00 AM EDT""<p><span style=\"color: rgb(51, 51, 51);\">The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the </span><strong style=\"color: rgb(51, 51, 51);\">Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks </strong><span style=\"color: rgb(51, 51, 51);\">to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’s </span><strong style=\"color: rgb(51, 51, 51);\">Academic Industrial Partnership (AIP) initiative </strong><span style=\"color: rgb(51, 51, 51);\">will focus on data integration and interoperability and will be followed by a second phase focused on algorithm development and performance testing. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3/UH3 activity code. Investigators with expertise and insights into AIP collaborations to develop and test AI-based tools using medical images and multimodal data for clinical diagnosis and treatment are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in building and managing academic and industrial partnerships will be encouraged and these investigators should also begin considering applying for this application.</span></p>"{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}359270[{"id":"01","description":"County governments"},{"id":"05","description":"Independent school districts"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"20","description":"Private institutions of higher education"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"00","description":"State governments"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"23","description":"Small businesses"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"}]"2025-06-06-00-00-00""Jun 06, 2025 11:54:57 AM EDT""2026-09-01-00-00-00""Jun 06, 2025 11:54:57 AM EDT""2900000""Sahana N. Kukke, PhD \r\nOffice of the Director/NIH Common Fund, DPCPSI, OD""ODPRIMED-AI@od.nih.gov""301-402-3756""2025-06-06-11-54-57"[{"id":"CA","description":"Cooperative Agreement"}]"Sep 01, 2026 12:00:00 AM EDT""ODPRIMED-AI@od.nih.gov""2026-09-01-00-00-00""Jul 01, 2025 12:00:00 AM EDT""2025-07-01-00-00-00""2,900,000"[{"id":"HL","description":"Health"}]"Nov 01, 2025 12:00:00 AM EDT""2025-11-01-00-00-00"0359270"D""Discretionary"{"id":428813,"revision":4,"cfdaNumber":"93.310","programTitle":"Trans-NIH Research Support","opportunityId":359270}21{"revision":1,"opportunityId":359270}"Y""Jan 21, 2026 11:36:38 AM EST""U""HHS-NIH11"2027false"Jun 06, 2025 11:54:18 AM EDT""Updated all estimated due dates.""Jun 06, 2025 12:00:00 AM EDT""Dec 01, 2026 12:00:00 AM EST""<p><span style=\"color: rgb(51, 51, 51);\">The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the </span><strong style=\"color: rgb(51, 51, 51);\">Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks </strong><span style=\"color: rgb(51, 51, 51);\">to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’s </span><strong style=\"color: rgb(51, 51, 51);\">Academic Industrial Partnership (AIP) initiative </strong><span style=\"color: rgb(51, 51, 51);\">will focus on data integration and interoperability and will be followed by a second phase focused on algorithm development and performance testing. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3/UH3 activity code. Investigators with expertise and insights into AIP collaborations to develop and test AI-based tools using medical images and multimodal data for clinical diagnosis and treatment are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in building and managing academic and industrial partnerships will be encouraged and these investigators should also begin considering applying for this application.</span></p>"{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}359270[{"id":"01","description":"County governments"},{"id":"05","description":"Independent school districts"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"20","description":"Private institutions of higher education"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"00","description":"State governments"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"23","description":"Small businesses"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"}]"2025-06-06-00-00-00""Sep 12, 2025 02:59:34 PM EDT""2026-12-01-00-00-00""Sep 12, 2025 02:59:34 PM EDT""2900000""Sahana N. Kukke, PhD \r\nOffice of the Director/NIH Common Fund, DPCPSI, OD""ODPRIMED-AI@od.nih.gov""301-402-3756""2025-09-12-14-59-34"[{"id":"CA","description":"Cooperative Agreement"}]"Dec 01, 2026 12:00:00 AM EST""ODPRIMED-AI@od.nih.gov""2026-12-01-00-00-00""Dec 11, 2025 12:00:00 AM EST""2025-12-11-00-00-00""2,900,000"[{"id":"HL","description":"Health"}]"Feb 11, 2026 12:00:00 AM EST""2026-02-11-00-00-00"1359270"D""Discretionary"{"id":428813,"revision":4,"cfdaNumber":"93.310","programTitle":"Trans-NIH Research Support","opportunityId":359270}32{"revision":2,"opportunityId":359270}"N""Jan 21, 2026 11:37:51 AM EST""U""HHS-NIH11"2027false"Jun 06, 2025 11:54:18 AM EDT""FON updated to reflect the anticipated NOFO.""Jun 06, 2025 12:00:00 AM EDT""Dec 01, 2026 12:00:00 AM EST""<p><span style=\"color: rgb(51, 51, 51);\">The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the </span><strong style=\"color: rgb(51, 51, 51);\">Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks </strong><span style=\"color: rgb(51, 51, 51);\">to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’s </span><strong style=\"color: rgb(51, 51, 51);\">Academic Industrial Partnership (AIP) initiative </strong><span style=\"color: rgb(51, 51, 51);\">will focus on data integration and interoperability and will be followed by a second phase focused on algorithm development and performance testing. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3/UH3 activity code. Investigators with expertise and insights into AIP collaborations to develop and test AI-based tools using medical images and multimodal data for clinical diagnosis and treatment are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in building and managing academic and industrial partnerships will be encouraged and these investigators should also begin considering applying for this application.</span></p>"{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}359270[{"id":"01","description":"County governments"},{"id":"05","description":"Independent school districts"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"20","description":"Private institutions of higher education"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"00","description":"State governments"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"23","description":"Small businesses"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"}]"2025-06-06-00-00-00""Jan 21, 2026 11:36:38 AM EST""2026-12-01-00-00-00""Jan 21, 2026 11:36:38 AM EST""2900000""Sahana N. Kukke, PhD \r\nOffice of the Director/NIH Common Fund, DPCPSI, OD""ODPRIMED-AI@od.nih.gov""301-402-3756""2026-01-21-11-36-38"[{"id":"CA","description":"Cooperative Agreement"}]"Dec 01, 2026 12:00:00 AM EST""ODPRIMED-AI@od.nih.gov""2026-12-01-00-00-00""Dec 11, 2025 12:00:00 AM EST""2025-12-11-00-00-00""2,900,000"[{"id":"HL","description":"Health"}]"Feb 11, 2026 12:00:00 AM EST""2026-02-11-00-00-00"2359270"D""Discretionary"{"id":428813,"revision":4,"cfdaNumber":"93.310","programTitle":"Trans-NIH Research Support","opportunityId":359270}43{"revision":3,"opportunityId":359270}"N""Jun 29, 2026 01:05:13 PM EDT""U""HHS-NIH11"2027false"Jun 06, 2025 11:54:18 AM EDT""Updated all estimated date fields.""Jun 06, 2025 12:00:00 AM EDT""Mar 01, 2027 12:00:00 AM EST""<p><span style=\"color: rgb(51, 51, 51);\">The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the </span><strong style=\"color: rgb(51, 51, 51);\">Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks </strong><span style=\"color: rgb(51, 51, 51);\">to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’s </span><strong style=\"color: rgb(51, 51, 51);\">Academic Industrial Partnership (AIP) initiative </strong><span style=\"color: rgb(51, 51, 51);\">will focus on data integration and interoperability and will be followed by a second phase focused on algorithm development and performance testing. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3/UH3 activity code. Investigators with expertise and insights into AIP collaborations to develop and test AI-based tools using medical images and multimodal data for clinical diagnosis and treatment are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in building and managing academic and industrial partnerships will be encouraged and these investigators should also begin considering applying for this application.</span></p>"{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}359270[{"id":"01","description":"County governments"},{"id":"05","description":"Independent school districts"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"20","description":"Private institutions of higher education"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"00","description":"State governments"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"23","description":"Small businesses"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"}]"2025-06-06-00-00-00""Jan 21, 2026 11:37:51 AM EST""2027-03-01-00-00-00""Jan 21, 2026 11:37:51 AM EST""2900000""Sahana N. Kukke, PhD \r\nOffice of the Director/NIH Common Fund, DPCPSI, OD""ODPRIMED-AI@od.nih.gov""301-402-3756""2026-01-21-11-37-51"[{"id":"CA","description":"Cooperative Agreement"}]"Mar 01, 2027 12:00:00 AM EST""ODPRIMED-AI@od.nih.gov""2027-03-01-00-00-00""Apr 17, 2026 12:00:00 AM EDT""2026-04-17-00-00-00""2,900,000"[{"id":"HL","description":"Health"}]"Jun 17, 2026 12:00:00 AM EDT""2026-06-17-00-00-00"3359270"D""Discretionary"{"id":428813,"revision":4,"cfdaNumber":"93.310","programTitle":"Trans-NIH Research Support","opportunityId":359270}55{"revision":5,"opportunityId":359270}"N""Jun 30, 2026 11:02:01 AM EDT""U""HHS-NIH11"2027false"Jun 06, 2025 11:54:18 AM EDT""Updated Opportunity Number and Title to match NOFO.""Jun 06, 2025 12:00:00 AM EDT""Mar 01, 2027 12:00:00 AM EST""<p><span style=\"color: rgb(51, 51, 51);\">The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the </span><strong style=\"color: rgb(51, 51, 51);\">Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks </strong><span style=\"color: rgb(51, 51, 51);\">to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’s </span><strong style=\"color: rgb(51, 51, 51);\">Academic Industrial Partnership (AIP) initiative </strong><span style=\"color: rgb(51, 51, 51);\">will focus on data integration and interoperability and will be followed by a second phase focused on algorithm development and performance testing. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3/UH3 activity code. Investigators with expertise and insights into AIP collaborations to develop and test AI-based tools using medical images and multimodal data for clinical diagnosis and treatment are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in building and managing academic and industrial partnerships will be encouraged and these investigators should also begin considering applying for this application.</span></p>"{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}359270[{"id":"01","description":"County governments"},{"id":"05","description":"Independent school districts"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"20","description":"Private institutions of higher education"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"00","description":"State governments"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"23","description":"Small businesses"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"}]"2025-06-06-00-00-00""Jun 29, 2026 01:05:13 PM EDT""2027-03-01-00-00-00""Jun 29, 2026 01:05:13 PM EDT""2900000""Sahana N. Kukke, PhD \r\nOffice of the Director/NIH Common Fund, DPCPSI, OD""ODPRIMED-AI@od.nih.gov""301-402-3756""2026-06-29-13-05-13"[{"id":"CA","description":"Cooperative Agreement"}]"Mar 01, 2027 12:00:00 AM EST""ODPRIMED-AI@od.nih.gov""2027-03-01-00-00-00""Apr 17, 2026 12:00:00 AM EDT""2026-04-17-00-00-00""2,900,000"[{"id":"HL","description":"Health"}]"Jun 17, 2026 12:00:00 AM EDT""2026-06-17-00-00-00"5359270"D""Discretionary"{"id":353491,"fileName":"RFA-RM-27-012-Full-Announcement.html","mimeType":"text/html;charset=UTF-8","createdDate":"Jun 30, 2026 11:02:13 AM EDT","fileLobSize":183696,"opportunityId":359270,"fileDescription":"RFA-RM-27-012-Full-Announcement.html","synopsisAttFolderId":80536}Source: Grants.gov (opportunity 359270), retrieved via the Grants.gov Search API. View the official posting , always confirm requirements and deadlines with the issuing agency.