Federal · SAM.gov · Virginia

Protein ENGineering (PENG)

Department of DefenseIssuing agency·Virginia·via the SAM.gov Get Opportunities API

69days left

Due Oct 19, 2026·Posted Aug 7, 2026

AI takeaways

DARPA is soliciting proposals for the Protein ENGineering (PENG) program to develop a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins, with work performed in VA.
The solicitation number is DARPA-PS-26-129, posted on 2026-08-07, with a tentative proposal due date of 2026-10-19.
Key dates include a Proposers Day on 2026-08-10, a question submittal deadline of 2026-08-17, and a mandatory abstract due date of 2026-08-24.
The program is structured as a 42-month, multi-phase effort (Phase 1A base of 18 months, Phase 1B option of 6 months, Phase 2 option of 18 months) with multiple awards anticipated.
The procurement method is a Solicitation, and the anticipated award type is Other Transaction Agreements for Prototype.
The issuing agency is the Department of Defense, through the Defense Advanced Research Projects Agency (DARPA).
The contact for this solicitation is the BAA Coordinator, reachable at PENG@darpa.mil.
Requirement: Proposers must submit an abstract before submitting a full proposal; abstracts are mandatory for this program.
Requirement: Non-U.S. organizations and/or individuals cannot participate in this solicitation.
Requirement: Proposers must use the provided Attachment F: DARPA Cost Proposal Spreadsheet in the development of their cost proposals.
Requirement: Proposers must complete and submit the Model Other Transaction for Prototype provided as Attachment G.
Requirement: Proposers must indicate whether they qualify as a nontraditional Defense contractor, have teamed with a nontraditional Defense contractor, or are providing a one-third cost share for this effort.
Requirement: Proposers must become CUI compliant by or before the end of Phase 1A to be eligible to participate in Phase 1B capability demonstration.

Pre-bid: Aug 10
Term: Eighteen months for Phase…
Method: Solicitation
Documents: 10 files

These takeaways are AI-generated and may be incomplete or wrong. Always verify every detail against the official documents before you bid.

Contact the buyer

BAA Coordinator

peng@darpa.milEmail

Location:

VA 222032114

Open in Maps ↗

Notice

be313c6423e841ae9572a0878b3d9bbb

DARPA-PS-26-129

Method

Solicitation

Duration

Eighteen months for Phase 1A. Six months for Phase 1B. Eighteen months for Phase 2.

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What this bid is asking for

AI-generated

Develop a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins.
Integrate modular targeting, generalizable effector chemistries, and multiplexed control systems into a single, unified pipeline.
Validate the integrated platform in high-fidelity cellular models (e.g., organoids) to provide an integrated proof-of-concept at the tissue level.
Deliver a fully integrated editing prototype platform capable of executing multiplexed, on-demand modifications to endogenous proteins by the end of the 42-month program.
Address program metrics for Programmable Targeting, Generalizable Chemistry, Multiplexing & Complexity, and Future Capabilities Readiness across at least three self-selected targets spanning distinct structural protein families.

Posted Scope of Work

The PENG program will establish a comprehensive, integrated platform composed of modular targeting, generalizable effector chemistries, and multiplexed control systems. Rather than developing isolated, target-specific tools, performers will integrate novel splicing, ligation, and co-translational techniques to directly recognize, modify, and rewrite endogenous proteins within complex biological architectures. Performers may explore multiple technical paths, progressively advancing their approaches from foundational validation to robust demonstrations of efficacy. Ultimately, this integrated platform will be validated in high-fidelity cellular models (e.g., organoids), to provide an integrated proof-of-concept at the tissue level.

Scope, read from the documentsAI-generated

The PENG program will establish a comprehensive, integrated platform composed of modular targeting, generalizable effector chemistries, and multiplexed control systems. Performers will integrate novel splicing, ligation, and co-translational techniques to directly recognize, modify, and rewrite endogenous proteins within complex biological architectures. The program is structured as a 42-month, multi-phase effort: Phase 1A (Base, 18 months) focuses on platform foundations; Phase 1B (Option Period 1, 6 months) is a capability demonstration; Phase 2 (Option Period 2, 18 months) focuses on advanced system integration. Performers must address metrics for Programmable Targeting, Generalizable Chemistry, Multiplexing & Complexity, and Future Capabilities Readiness. The culminating prototype deliverable will be a validated system that provides tunable, reversible, and context-dependent control over physiological functions.

Questions & answers

AI-generated

What is the due date for proposals?

The tentative proposal due date is October 19, 2026, at 4:00 p.m. Eastern Time.

Is an abstract required before submitting a full proposal?

Yes, abstracts are mandatory for this program, and proposers are required to submit an abstract before submitting a full proposal.

What is the period of performance?

The period of performance is eighteen months for Phase 1A, six months for Phase 1B, and eighteen months for Phase 2.

What types of awards are anticipated?

The anticipated types of instruments that may be awarded are Other Transaction Agreements for Prototype.

Can non-U.S. organizations participate?

No, non-U.S. organizations and/or individuals cannot participate in this solicitation.

Documents

Download zip

DARPA-PS-26-129.pdfPDF

Preview Download

Attachment_I_Schedule_of_Milestones_and_Payments.xlsxXLSX

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Attachment_E_Proposal_Instructions_and_Volume_II_Template_Cost.docxDOCX

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Attachment_H_Task_Description_Document__TDD_.docxDOCX

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Attachment_G_Model_Other_Transaction_for_Prototype.docxDOCX

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Attachment_F_DARPA_Cost_Proposal_Spreadsheet.xlsxXLSX

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Attachment_D_Proposal_Instructions_and_Volume_I_Template_Technical_and_Management.docxDOCX

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Attachment_C_Proposal_Summary_Slide_Template.pptxPPTX

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Attachment_B_Abstract_Instructions_and_Template.docxDOCX

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Attachment_A_Abstract_Summary_Side.pptxPPTX

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Full source recordEvery field SAM.gov published, untouched

Hit

be313c6423e841ae9572a0878b3d9bbb

Type

Code: o
Value: Solicitation

Type

opportunity

Award

Awardee

Title

Protein ENGineering (PENG)

R Score

Is Active

Yes

Is Canceled

Publish Date

Aug 7, 2026

Descriptions

Content: The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the development of a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins. The goal of the Protein ENGineering
Last Modified Date: Aug 7, 2026

Modified Date

Aug 7, 2026

Response Date

Oct 19, 2026

Modifications

Count: 0

Response Time Zone

America/New_York

Response Date Actual

Oct 19, 2026

Solicitation Number

DARPA-PS-26-129

Organization Hierarchy

Code

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DEF ADVANCED RESEARCH PROJECTS AGCY

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State: "VA"
Country: "USA"
Street Address: "675 NORTH RANDOLPH STREET"

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Cgac

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Parent Org

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Start Date

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Created Date

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L1 Short Name

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Has Contracts

Yes

Is Source Fpds

Yes

Org Addresses

City: ARLINGTON
Type: M
State: VA
Org Key: 500035490
Zipcode: 222032114
Created By: MIGRATOR_NEW_ATOM_FEED
Mod Status: active
Address Key: 500668784
Country Code: USA
Created Date: May 2, 2004
Is Source Fpds: Yes
Street Address: 675 NORTH RANDOLPH STREET
Last Modified By: FPDSADMIN
Last Modified Date: Sep 17, 2013

Parent Org Key

300000412

Code Hierarchy

9700.97AE.HR0011

Org Legacy List

Source: LEGACY_OFFICES_FBO_DOD.xls
Org Key: 500035490
Legacy Id: 2597447818538ac164e1401b140bbb6e
Created By: nithin.john-emanuel@gsa.gov_oda
Legacy Key: 6731
Legacy Name: Contracts Management Office
Created Date: Oct 16, 2019
Last Modified By: nithin.john-emanuel@gsa.gov_oda
Last Modified Date: Oct 16, 2019
Legacy System Name: FBO

Full Parent Path

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Last Modified By

FPDSADMIN_NEW_ATOM_FEED

Org Office Types

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Is Latest: Yes
Office Id: 2135377
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Start Date: Oct 1, 2003
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Org Key: 500035490
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Created By: FH_Job
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Office Type Id: 3
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Office Type Name: FINANCIAL ASSISTANCE AWARDS
Last Modified Date: Jan 8, 2020

Last Modified Date

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Full Parent Path Name

DEPT OF DEFENSE.DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA).DEF ADVANCED RESEARCH PROJECTS AGCY

Type

Solicitation

Title

Protein ENGineering (PENG)

Active

Yes

Detail

Type

Naics

Code: 541714
Type: primary

Title

Protein ENGineering (PENG)

Archive

Date: Nov 18, 2026
Type: autocustom

Permissions

IVL

Read: Yes
Create: Yes
Delete: Yes
Update: Yes

Solicitation

Deadlines

Response: Oct 19, 2026
Response Tz: America/New_York

Organization Id

500035490

Point Of Contact

Type: primary
Email: PENG@darpa.mil
Full Name: BAA Coordinator

Classification Code

AC12

Solicitation Number

DARPA-PS-26-129

Additional Reporting

none

Ui Link

https://sam.gov/opp/be313c6423e841ae9572a0878b3d9bbb/view

History

Links

Self

Href: https://86samdotgovopportunitiesmodern.prod.apps-internal.prod-iae.bsp.gsa.gov/opps/v2/opportunities/be313c6423e841ae9572a0878b3d9bbb/history{?postedFrom}
Templated: Yes

History

Index: 1
Title: Protein ENGineering (PENG)
Latest: 1
Deleted: 0
Action Date: 2026-08-07T15:37:55.932+00
Action Type: publish
Posted Date: 2026-08-07T15:37:55.926+00
Request Type: submit
Cancel Notice: 0
Archive Notice: 0
Opportunity Id: be313c6423e841ae9572a0878b3d9bbb
Procurement Type: o
Solicitation Number: DARPA-PS-26-129

Base Type

Solicitation

Notice Id

be313c6423e841ae9572a0878b3d9bbb

Naics Code

541714

Resources

Attachments

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Opportunity Id

be313c6423e841ae9572a0878b3d9bbb

Department

DEPARTMENT OF DEFENSE

Posted Date

Aug 7, 2026

Detail Fetched

Yes

Office Address

State: VA
Zipcode: 222032114
Country Code: USA

Resource Links

History Fetched

Yes

Point Of Contact

Type: primary
Email: PENG@darpa.mil
Full Name: BAA Coordinator

Description Text

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the development of a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins. The goal of the Protein ENGineering (PENG) program is to transition proteome engineering from a collection of isolated, bespoke tools into a universal, software-defined discipline. The PENG program will establish a comprehensive, integrated platform composed of modular targeting, generalizable effector chemistries, and multiplexed control systems. Rather than developing isolated, target-specific tools, performers will integrate novel splicing, ligation, and co-translational techniques to directly recognize, modify, and rewrite endogenous proteins within complex biological architectures. Performers may explore multiple technical paths, progressively advancing their approaches from foundational validation to robust demonstrations of efficacy. Ultimately, this integrated platform will be validated in high-fidelity cellular models (e.g., organoids), to provide an integrated proof-of-concept at the tissue level.

Resources Fetched

Yes

Response Dead Line

Oct 19, 2026

Full Parent Path Name

DEPARTMENT OF DEFENSE.DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA).DEF ADVANCED RESEARCH PROJECTS AGCY

Solicitation Number

DARPA-PS-26-129

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Source: SAM.gov (notice be313c6423e841ae9572a0878b3d9bbb), retrieved via the SAM.gov Get Opportunities API. View the official posting , always confirm requirements and deadlines with the issuing agency.

Federal · SAM.gov · Virginia

Protein ENGineering (PENG)

Department of DefenseIssuing agency·Virginia·via the SAM.gov Get Opportunities API

69days left

Due Oct 19, 2026·Posted Aug 7, 2026

AI takeaways

DARPA is soliciting proposals for the Protein ENGineering (PENG) program to develop a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins, with work performed in VA.
The solicitation number is DARPA-PS-26-129, posted on 2026-08-07, with a tentative proposal due date of 2026-10-19.
Key dates include a Proposers Day on 2026-08-10, a question submittal deadline of 2026-08-17, and a mandatory abstract due date of 2026-08-24.
The program is structured as a 42-month, multi-phase effort (Phase 1A base of 18 months, Phase 1B option of 6 months, Phase 2 option of 18 months) with multiple awards anticipated.
The procurement method is a Solicitation, and the anticipated award type is Other Transaction Agreements for Prototype.
The issuing agency is the Department of Defense, through the Defense Advanced Research Projects Agency (DARPA).
The contact for this solicitation is the BAA Coordinator, reachable at PENG@darpa.mil.
Requirement: Proposers must submit an abstract before submitting a full proposal; abstracts are mandatory for this program.
Requirement: Non-U.S. organizations and/or individuals cannot participate in this solicitation.
Requirement: Proposers must use the provided Attachment F: DARPA Cost Proposal Spreadsheet in the development of their cost proposals.
Requirement: Proposers must complete and submit the Model Other Transaction for Prototype provided as Attachment G.
Requirement: Proposers must indicate whether they qualify as a nontraditional Defense contractor, have teamed with a nontraditional Defense contractor, or are providing a one-third cost share for this effort.
Requirement: Proposers must become CUI compliant by or before the end of Phase 1A to be eligible to participate in Phase 1B capability demonstration.

Pre-bid: Aug 10
Term: Eighteen months for Phase…
Method: Solicitation
Documents: 10 files

These takeaways are AI-generated and may be incomplete or wrong. Always verify every detail against the official documents before you bid.

Contact the buyer

BAA Coordinator

peng@darpa.milEmail

Location:

VA 222032114

Open in Maps ↗

Notice

be313c6423e841ae9572a0878b3d9bbb

DARPA-PS-26-129

Method

Solicitation

Duration

Eighteen months for Phase 1A. Six months for Phase 1B. Eighteen months for Phase 2.

More science & technology research bids in Virginia, weekly.

We post new science & technology research opportunities in Virginia as agencies publish them. Get them in one email — free, and unsubscribe whenever.

What this bid is asking for

AI-generated

Develop a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins.
Integrate modular targeting, generalizable effector chemistries, and multiplexed control systems into a single, unified pipeline.
Validate the integrated platform in high-fidelity cellular models (e.g., organoids) to provide an integrated proof-of-concept at the tissue level.
Deliver a fully integrated editing prototype platform capable of executing multiplexed, on-demand modifications to endogenous proteins by the end of the 42-month program.
Address program metrics for Programmable Targeting, Generalizable Chemistry, Multiplexing & Complexity, and Future Capabilities Readiness across at least three self-selected targets spanning distinct structural protein families.

Posted Scope of Work

Scope, read from the documentsAI-generated

Questions & answers

AI-generated

What is the due date for proposals?

The tentative proposal due date is October 19, 2026, at 4:00 p.m. Eastern Time.

Is an abstract required before submitting a full proposal?

Yes, abstracts are mandatory for this program, and proposers are required to submit an abstract before submitting a full proposal.

What is the period of performance?

The period of performance is eighteen months for Phase 1A, six months for Phase 1B, and eighteen months for Phase 2.

What types of awards are anticipated?

The anticipated types of instruments that may be awarded are Other Transaction Agreements for Prototype.

Can non-U.S. organizations participate?

No, non-U.S. organizations and/or individuals cannot participate in this solicitation.

Documents

Download zip

DARPA-PS-26-129.pdfPDF

Preview Download

Attachment_I_Schedule_of_Milestones_and_Payments.xlsxXLSX

Preview Download

Attachment_E_Proposal_Instructions_and_Volume_II_Template_Cost.docxDOCX

Preview Download

Attachment_H_Task_Description_Document__TDD_.docxDOCX

Preview Download

Attachment_G_Model_Other_Transaction_for_Prototype.docxDOCX

Preview Download

Attachment_F_DARPA_Cost_Proposal_Spreadsheet.xlsxXLSX

Preview Download

Attachment_D_Proposal_Instructions_and_Volume_I_Template_Technical_and_Management.docxDOCX

Preview Download

Attachment_C_Proposal_Summary_Slide_Template.pptxPPTX

Preview Download

Attachment_B_Abstract_Instructions_and_Template.docxDOCX

Preview Download

Attachment_A_Abstract_Summary_Side.pptxPPTX

Preview Download

Full source recordEvery field SAM.gov published, untouched

Hit

be313c6423e841ae9572a0878b3d9bbb

Type

Code: o
Value: Solicitation

Type

opportunity

Award

Awardee

Title

Protein ENGineering (PENG)

R Score

Is Active

Yes

Is Canceled

Publish Date

Aug 7, 2026

Descriptions

Content: The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the development of a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins. The goal of the Protein ENGineering
Last Modified Date: Aug 7, 2026

Modified Date

Aug 7, 2026

Response Date

Oct 19, 2026

Modifications

Count: 0

Response Time Zone

America/New_York

Response Date Actual

Oct 19, 2026

Solicitation Number

DARPA-PS-26-129

Organization Hierarchy

Code

9700

Name

DEPT OF DEFENSE

Type

DEPARTMENT

Level

Status

active

Address

Organization Id

100000000

Code

97AE

Name

DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)

Type

AGENCY

Level

Status

active

Address

Organization Id

300000412

Code

HR0011

Name

DEF ADVANCED RESEARCH PROJECTS AGCY

Type

OFFICE

Level

Status

active

Address

Zip: "222032114"
City: "ARLINGTON"
State: "VA"
Country: "USA"
Street Address: "675 NORTH RANDOLPH STREET"

Organization Id

500035490

Org

Cgac

097

Code

HR0011

Name

DEF ADVANCED RESEARCH PROJECTS AGCY

Type

OFFICE

Level

L1 Name

DEPT OF DEFENSE

L2 Name

DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)

L3 Name

DEF ADVANCED RESEARCH PROJECTS AGCY

Org Key

500035490

Aac Code

HR0011

Fpds Code

97AE

L1 Org Key

100000000

L2 Org Key

300000412

Created By

MIGRATOR_NEW_ATOM_FEED

Fpds Org Id

HR0011

Mod Status

ACTIVE

Parent Org

DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)

Start Date

Oct 1, 2003

Created Date

May 2, 2004

L1 Short Name

DOD

Has Contracts

Yes

Is Source Fpds

Yes

Org Addresses

City: ARLINGTON
Type: M
State: VA
Org Key: 500035490
Zipcode: 222032114
Created By: MIGRATOR_NEW_ATOM_FEED
Mod Status: active
Address Key: 500668784
Country Code: USA
Created Date: May 2, 2004
Is Source Fpds: Yes
Street Address: 675 NORTH RANDOLPH STREET
Last Modified By: FPDSADMIN
Last Modified Date: Sep 17, 2013

Parent Org Key

300000412

Code Hierarchy

9700.97AE.HR0011

Org Legacy List

Source: LEGACY_OFFICES_FBO_DOD.xls
Org Key: 500035490
Legacy Id: 2597447818538ac164e1401b140bbb6e
Created By: nithin.john-emanuel@gsa.gov_oda
Legacy Key: 6731
Legacy Name: Contracts Management Office
Created Date: Oct 16, 2019
Last Modified By: nithin.john-emanuel@gsa.gov_oda
Last Modified Date: Oct 16, 2019
Legacy System Name: FBO

Full Parent Path

100000000.300000412.500035490

Last Modified By

FPDSADMIN_NEW_ATOM_FEED

Org Office Types

Org Key: 500035490
Position: 3
Is Latest: Yes
Office Id: 2135377
Created By: FH-RE-INGESTION
Mod Status: Yes
Start Date: Oct 1, 2003
Office Type: 1
Created Date: Jul 13, 2020
Office Type Id: 1
Last Modified By: FH-RE-INGESTION
Office Type Name: CONTRACT FUNDING
Last Modified Date: Jul 13, 2020

Org Key: 500035490
Position: 4
Is Latest: Yes
Office Id: 2135378
Created By: FH-RE-INGESTION
Mod Status: Yes
Start Date: Oct 1, 2003
Office Type: 5
Created Date: Jul 13, 2020
Office Type Id: 5
Last Modified By: FH-RE-INGESTION
Office Type Name: FINANCIAL ASSISTANCE FUNDING
Last Modified Date: Jul 13, 2020

Org Key: 500035490
Position: 1
Is Latest: Yes
Office Id: 2135379
Created By: FH-RE-INGESTION
Mod Status: Yes
Start Date: Oct 1, 2003
Office Type: 2
Created Date: Jul 13, 2020
Office Type Id: 2
Last Modified By: FH-RE-INGESTION
Office Type Name: CONTRACT AWARDS
Last Modified Date: Jul 13, 2020

Org Key: 500035490
Position: 2
Is Latest: Yes
Office Id: 2135376
Created By: FH_Job
Mod Status: Yes
Start Date: Oct 1, 2003
Office Type: 3
Created Date: Sep 30, 2018
Office Type Id: 3
Last Modified By: IAE_29337_DOD
Office Type Name: FINANCIAL ASSISTANCE AWARDS
Last Modified Date: Jan 8, 2020

Last Modified Date

Sep 17, 2013

Full Parent Path Name

DEPT OF DEFENSE.DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA).DEF ADVANCED RESEARCH PROJECTS AGCY

Type

Solicitation

Title

Protein ENGineering (PENG)

Active

Yes

Detail

Type

Naics

Code: 541714
Type: primary

Title

Protein ENGineering (PENG)

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