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The overarching goal of this notice of funding opportunity (NOFO) and its companion opportunities is to establish the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Program to support development of innovative, reliable, cost-effective, and sustainable multimodal AI-based clinical decision support (CDS) tools. PRIMED-AI CDS tools are based on the integration of clinical imaging with other types of multimodal health data to enhance care for patients with a wide range of health conditions. The PRIMED-AI Program seeks to catalyze the adoption of AI-based CDS tools into clinical workflows to enable novel personalized medicine strategies that address significant health challenges.
The purpose of this NOFO is to solicit applications for the design, development, and preliminary validation of robust frameworks for the application of multimodal-artificial intelligence (AI) models for clinical use. Frameworks developed through these awards would populate a "playbook", defined as a collection of actionable guidelines, standardized protocols, and/or standard operating procedures (SOPs) for reliable and effective development and deployment of multimodal AI tools. It is expected that the frameworks delineated in this playbook will directly address PRIMED-AI objectives and needs, while also remaining flexible enough to enable sufficient extensibility and interoperability for use across a broad spectrum of multimodal biomedical AI applications, both internal and external to the PRIMED-AI Program.
The purpose of this NOFO is to solicit applications for the design, development, and preliminary validation of robust frameworks for the application of multimodal-artificial intelligence (AI) models for clinical use. Frameworks developed through these awards would populate a 'playbook', defined as a collection of actionable guidelines, standardized protocols, and/or standard operating procedures (SOPs) for reliable and effective development and deployment of multimodal AI tools.
"20""Private institutions of higher education""06""Public and State controlled institutions of higher education""11""Native American tribal organizations (other than Federally recognized tribal governments)""08""Public housing authorities/Indian housing authorities""23""Small businesses""05""Independent school districts""12""Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education""01""County governments""22""For profit organizations other than small businesses""00""State governments""07""Native American tribal governments (Federally recognized)""CA""Cooperative Agreement""HL""Health""06""Public and State controlled institutions of higher education""11""Native American tribal organizations (other than Federally recognized tribal governments)""25""Others (see text field entitled \"Additional Information on Eligibility\" for clarification)""12""Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education""22""For profit organizations other than small businesses""07""Native American tribal governments (Federally recognized)""20""Private institutions of higher education""08""Public housing authorities/Indian housing authorities""04""Special district governments""23""Small businesses""13""Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education""02""City or township governments""05""Independent school districts""01""County governments""00""State governments""CA""Cooperative Agreement""HL""Health""NIH""HHS-NIH11""HHS-NIH11""National Institutes of Health""HHS""HHS""HHS""HHS""Department of Health and Human Services""HHS"{"id":428814,"revision":4,"cfdaNumber":"93.310","programTitle":"Trans-NIH Research Support","opportunityId":359271}10{"revision":0,"opportunityId":359271}"Y""Sep 12, 2025 02:58:00 PM EDT""U""HHS-NIH11"2026false"Jun 06, 2025 12:01:59 PM EDT""Jun 06, 2025 12:00:00 AM EDT""Sep 01, 2026 12:00:00 AM EDT""<p><span style=\"color: rgb(51, 51, 51);\">The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the </span><strong style=\"color: rgb(51, 51, 51);\">Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks </strong><span style=\"color: rgb(51, 51, 51);\">to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’s</span><strong style=\"color: rgb(51, 51, 51);\">Playbook initiative </strong><span style=\"color: rgb(51, 51, 51);\">will fund the development and initial testing of discrete projects that deliver “playbooks” of frameworks for responsible use of PRIMED-AI models, error mitigation and technical management of data and algorithms, data ontology/linkage, and preparation for regulatory approval (e.g., FDA). Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3 activity code. Investigators with expertise and insights into AI-driven integration of clinical imaging with other complex and multiscale health data are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in harmonization processes for appropriate development and validation of multimodal AI tools to develop AI-based technologies leveraging multimodal data will be encouraged and these investigators should also begin considering applying for this application.</span></p>"{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}359271[{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"00","description":"State governments"},{"id":"20","description":"Private institutions of higher education"},{"id":"23","description":"Small businesses"},{"id":"05","description":"Independent school districts"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"01","description":"County governments"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"}]"2025-06-06-00-00-00""Jun 06, 2025 12:01:59 PM EDT""2026-09-01-00-00-00""Jun 06, 2025 12:01:59 PM EDT""650000""Sahana N. Kukke, PhD \r\nOffice of the Director/NIH Common Fund, DPCPSI, OD""ODPRIMED-AI@od.nih.gov""301-402-3756""2025-06-06-12-01-59"[{"id":"CA","description":"Cooperative Agreement"}]"Sep 01, 2026 12:00:00 AM EDT""ODPRIMED-AI@od.nih.gov""2026-09-01-00-00-00""Jul 01, 2025 12:00:00 AM EDT""2025-07-01-00-00-00""650,000"[{"id":"HL","description":"Health"}]"Nov 01, 2025 12:00:00 AM EDT""2025-11-01-00-00-00"0359271"D""Discretionary"{"id":428814,"revision":4,"cfdaNumber":"93.310","programTitle":"Trans-NIH Research Support","opportunityId":359271}21{"revision":1,"opportunityId":359271}"Y""Jan 21, 2026 11:32:17 AM EST""U""HHS-NIH11"2027false"Jun 06, 2025 12:01:59 PM EDT""Updated all estimated due dates.""Jun 06, 2025 12:00:00 AM EDT""Dec 01, 2026 12:00:00 AM EST""<p><span style=\"color: rgb(51, 51, 51);\">The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the </span><strong style=\"color: rgb(51, 51, 51);\">Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks </strong><span style=\"color: rgb(51, 51, 51);\">to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’s</span><strong style=\"color: rgb(51, 51, 51);\">Playbook initiative </strong><span style=\"color: rgb(51, 51, 51);\">will fund the development and initial testing of discrete projects that deliver “playbooks” of frameworks for responsible use of PRIMED-AI models, error mitigation and technical management of data and algorithms, data ontology/linkage, and preparation for regulatory approval (e.g., FDA). Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3 activity code. Investigators with expertise and insights into AI-driven integration of clinical imaging with other complex and multiscale health data are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in harmonization processes for appropriate development and validation of multimodal AI tools to develop AI-based technologies leveraging multimodal data will be encouraged and these investigators should also begin considering applying for this application.</span></p>"{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}359271[{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"00","description":"State governments"},{"id":"20","description":"Private institutions of higher education"},{"id":"23","description":"Small businesses"},{"id":"05","description":"Independent school districts"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"01","description":"County governments"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"}]"2025-06-06-00-00-00""Sep 12, 2025 02:58:00 PM EDT""2026-12-01-00-00-00""Sep 12, 2025 02:58:00 PM EDT""650000""Sahana N. Kukke, PhD \r\nOffice of the Director/NIH Common Fund, DPCPSI, OD""ODPRIMED-AI@od.nih.gov""301-402-3756""2025-09-12-14-58-00"[{"id":"CA","description":"Cooperative Agreement"}]"Dec 01, 2026 12:00:00 AM EST""ODPRIMED-AI@od.nih.gov""2026-12-01-00-00-00""Dec 11, 2025 12:00:00 AM EST""2025-12-11-00-00-00""650,000"[{"id":"HL","description":"Health"}]"Feb 11, 2026 12:00:00 AM EST""2026-02-11-00-00-00"1359271"D""Discretionary"{"id":428814,"revision":4,"cfdaNumber":"93.310","programTitle":"Trans-NIH Research Support","opportunityId":359271}32{"revision":2,"opportunityId":359271}"N""Jan 21, 2026 11:35:21 AM EST""U""HHS-NIH11"2027false"Jun 06, 2025 12:01:59 PM EDT""FON updated to reflect the anticipated NOFO.""Jun 06, 2025 12:00:00 AM EDT""Dec 01, 2026 12:00:00 AM EST""<p><span style=\"color: rgb(51, 51, 51);\">The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the </span><strong style=\"color: rgb(51, 51, 51);\">Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks </strong><span style=\"color: rgb(51, 51, 51);\">to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’s</span><strong style=\"color: rgb(51, 51, 51);\">Playbook initiative </strong><span style=\"color: rgb(51, 51, 51);\">will fund the development and initial testing of discrete projects that deliver “playbooks” of frameworks for responsible use of PRIMED-AI models, error mitigation and technical management of data and algorithms, data ontology/linkage, and preparation for regulatory approval (e.g., FDA). Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3 activity code. Investigators with expertise and insights into AI-driven integration of clinical imaging with other complex and multiscale health data are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in harmonization processes for appropriate development and validation of multimodal AI tools to develop AI-based technologies leveraging multimodal data will be encouraged and these investigators should also begin considering applying for this application.</span></p>"{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}359271[{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"00","description":"State governments"},{"id":"20","description":"Private institutions of higher education"},{"id":"23","description":"Small businesses"},{"id":"05","description":"Independent school districts"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"01","description":"County governments"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"}]"2025-06-06-00-00-00""Jan 21, 2026 11:32:17 AM EST""2026-12-01-00-00-00""Jan 21, 2026 11:32:17 AM EST""650000""Sahana N. Kukke, PhD \r\nOffice of the Director/NIH Common Fund, DPCPSI, OD""ODPRIMED-AI@od.nih.gov""301-402-3756""2026-01-21-11-32-17"[{"id":"CA","description":"Cooperative Agreement"}]"Dec 01, 2026 12:00:00 AM EST""ODPRIMED-AI@od.nih.gov""2026-12-01-00-00-00""Dec 11, 2025 12:00:00 AM EST""2025-12-11-00-00-00""650,000"[{"id":"HL","description":"Health"}]"Feb 11, 2026 12:00:00 AM EST""2026-02-11-00-00-00"2359271"D""Discretionary"{"id":428814,"revision":4,"cfdaNumber":"93.310","programTitle":"Trans-NIH Research Support","opportunityId":359271}43{"revision":3,"opportunityId":359271}"Y""Jun 29, 2026 01:05:39 PM EDT""U""HHS-NIH11"2027false"Jun 06, 2025 12:01:59 PM EDT""Updated all estimated date fields""Jun 06, 2025 12:00:00 AM EDT""Apr 01, 2027 12:00:00 AM EDT""<p><span style=\"color: rgb(51, 51, 51);\">The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the </span><strong style=\"color: rgb(51, 51, 51);\">Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks </strong><span style=\"color: rgb(51, 51, 51);\">to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’s</span><strong style=\"color: rgb(51, 51, 51);\">Playbook initiative </strong><span style=\"color: rgb(51, 51, 51);\">will fund the development and initial testing of discrete projects that deliver “playbooks” of frameworks for responsible use of PRIMED-AI models, error mitigation and technical management of data and algorithms, data ontology/linkage, and preparation for regulatory approval (e.g., FDA). Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3 activity code. Investigators with expertise and insights into AI-driven integration of clinical imaging with other complex and multiscale health data are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in harmonization processes for appropriate development and validation of multimodal AI tools to develop AI-based technologies leveraging multimodal data will be encouraged and these investigators should also begin considering applying for this application.</span></p>"{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}359271[{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"00","description":"State governments"},{"id":"20","description":"Private institutions of higher education"},{"id":"23","description":"Small businesses"},{"id":"05","description":"Independent school districts"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"01","description":"County governments"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"}]"2025-06-06-00-00-00""Jan 21, 2026 11:35:21 AM EST""2027-04-01-00-00-00""Jan 21, 2026 11:35:21 AM EST""650000""Sahana N. Kukke, PhD \r\nOffice of the Director/NIH Common Fund, DPCPSI, OD""ODPRIMED-AI@od.nih.gov""301-402-3756""2026-01-21-11-35-21"[{"id":"CA","description":"Cooperative Agreement"}]"Apr 01, 2027 12:00:00 AM EDT""ODPRIMED-AI@od.nih.gov""2027-04-01-00-00-00""Apr 17, 2026 12:00:00 AM EDT""2026-04-17-00-00-00""650,000"[{"id":"HL","description":"Health"}]"Jun 17, 2026 12:00:00 AM EDT""2026-06-17-00-00-00"3359271"D""Discretionary"{"id":428814,"revision":4,"cfdaNumber":"93.310","programTitle":"Trans-NIH Research Support","opportunityId":359271}55{"revision":5,"opportunityId":359271}"N""Jun 30, 2026 11:01:47 AM EDT""U""HHS-NIH11"2027false"Jun 06, 2025 12:01:59 PM EDT""Updated Opportunity Number and Title to match NOFO.""Jun 06, 2025 12:00:00 AM EDT""Apr 01, 2027 12:00:00 AM EDT""<p><span style=\"color: rgb(51, 51, 51);\">The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the </span><strong style=\"color: rgb(51, 51, 51);\">Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks </strong><span style=\"color: rgb(51, 51, 51);\">to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’s</span><strong style=\"color: rgb(51, 51, 51);\">Playbook initiative </strong><span style=\"color: rgb(51, 51, 51);\">will fund the development and initial testing of discrete projects that deliver “playbooks” of frameworks for responsible use of PRIMED-AI models, error mitigation and technical management of data and algorithms, data ontology/linkage, and preparation for regulatory approval (e.g., FDA). Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3 activity code. Investigators with expertise and insights into AI-driven integration of clinical imaging with other complex and multiscale health data are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in harmonization processes for appropriate development and validation of multimodal AI tools to develop AI-based technologies leveraging multimodal data will be encouraged and these investigators should also begin considering applying for this application.</span></p>"{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}359271[{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"00","description":"State governments"},{"id":"20","description":"Private institutions of higher education"},{"id":"23","description":"Small businesses"},{"id":"05","description":"Independent school districts"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"01","description":"County governments"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"}]"2025-06-06-00-00-00""Jun 29, 2026 01:05:39 PM EDT""2027-04-01-00-00-00""Jun 29, 2026 01:05:39 PM EDT""650000""Sahana N. Kukke, PhD \r\nOffice of the Director/NIH Common Fund, DPCPSI, OD""ODPRIMED-AI@od.nih.gov""301-402-3756""2026-06-29-13-05-39"[{"id":"CA","description":"Cooperative Agreement"}]"Apr 01, 2027 12:00:00 AM EDT""ODPRIMED-AI@od.nih.gov""2027-04-01-00-00-00""Apr 17, 2026 12:00:00 AM EDT""2026-04-17-00-00-00""650,000"[{"id":"HL","description":"Health"}]"Jun 17, 2026 12:00:00 AM EDT""2026-06-17-00-00-00"5359271"D""Discretionary"{"id":353490,"fileName":"RFA-RM-27-011-Full-Announcement.html","mimeType":"text/html;charset=UTF-8","createdDate":"Jun 30, 2026 11:02:00 AM EDT","fileLobSize":151256,"opportunityId":359271,"fileDescription":"RFA-RM-27-011-Full-Announcement.html","synopsisAttFolderId":80535}Source: Grants.gov (opportunity 359271), retrieved via the Grants.gov Search API. View the official posting , always confirm requirements and deadlines with the issuing agency.